The Faculty


Biophysical basis of epithelial morphogenesis and organ shape


BS Chemistry, University of Oregon, 1996
PhD Biochemistry, University of California, San Francisco, 2003

Research Summary

During development, discrete organs and entire body plans emerge from the coordinate actions of individual cells. These complex morphogenetic events require dynamic regulation of cell shape, polarity and adhesion across cell populations. Our lab seeks to understand how these diverse cellular behaviors are orchestrated to produce an organ's functional shape.

To this end, we are using genetic, cell biological and live imaging approaches in Drosophila to investigate how a simple, ovarian structure called and egg chamber lengthens as it grows. We are particularly interested in the roles that collective cell migration and basement membrane remodeling play in this process. Please visit our lab website for more information about the strengths of this system and the specific questions that we pursue.

Selected Publications

Zajac AL and Horne-Badovinac S (2021). Basement membrane protein secretion is directed to a basal region of the basolateral membrane in epithelial cells by kinesin-3 and kinesin-1 motors. (in revision at Current Biology).

Casler JC, Zajac AL, Valbuena FM, Sparvoli D, Jeyifous O, Turkewitz AP, Horne-Badovinac S, Green WN, Glick BS. (2020). ESCargo: a regulatable fluorescent secretory cargo for diverse model organisms. Molecular Biology of the Cell, 31(26), 2892-2903.

Horne-Badovinac S. (2020). The Drosophila micropyle as a system to study how epithelia build complex extracellular structures. Philosophical Transactions of the Royal Society B, 375 (1809).

Horne-Badovinac S (2020). Mobilizing the matrix for organ morphogenesis. Developmental Cell, 54(1), 1-2.

Cerqueira Campos F, Dennis C, Alegot H, Fritsch C, Isabella A, Pouchin P, Bardot O, Horne-Badovinac S, Mirouse V. (2020). Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation. Development 147(7).

Williams AM and Horne-Badovinac S (2020). Looking deeper into tissue elongation. Nature Reviews Molecular Cell Biology.

Davis MN, Horne-Badovinac S, and Naba A (2019). In-silico definition of the Drosophila melanogaster matrisome. Matrix Biology Plus, Vol 4.

Dent LG, Manning SA, Kroeger B, Williams AM, Hilmi AJS, Crea L, Kondo S, Horne-Badovinac S, and Harvey KF (2019). The Pix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development. PLoS Genetics, 15(5).

Stedden CG, Menegas W, Williams AM, Zajac AL, Cheng S, Özkan E and Horne-Badovinac S (2019). Planar polarized Semaphorin-5c and Plexin A promote the collective migration of epithelial cells in Drosophila. Current Biology, 29, 908–920.