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I’m combining computational physics and machine learning to elucidate chromatin remodeling and epigenetic regulation

A hallmark feature of cancer cells is their procurement of genetic and epigenetic mutations that induce genomic instability and disrupt gene expression. The organization of DNA into chromatin plays a particularly central role in maintaining genomic integrity and regulating transcription; however, the molecular mechanisms by which chromatin structure regulates gene expression remains elusive. By leveraging high-performance computing and machine learning techniques, our current research seeks to resolve the organizational principles of nucleosome folding and elucidate the higher-order structural changes induced by epigenetic modifications