Research Description

We develop interdisciplinary approaches and tools to study how the immune system functions across biological scales ranging from individual molecules and cells, to tissues, to a mammalian organism. We aim to characterize the multi-scale processes at play during protective immune responses, and use this information to manipulate immunity against disease.

Selected Publications

Pairwise Stimulations of Pathogen-Sensing Pathways Predict Immune Responses to Multi-Adjuvant Combinations
Pandey S, Gruenbaum A, Kashanova T, Mertins P, Cluzel P, Chevrier N.
Cell Systems 11(5):495-508.e10 (2020). PubMed PMID: 33113356. Scripts: https://github.com/chevrierlab/combos-paper

A Whole-Tissue RNA-seq Toolkit for Organism-Wide Studies of Gene Expression with PME-seq
Pandey S, Takahama M, Gruenbaum A, Zewde M, Cheronis K, Chevrier N. Nature Protocols 15(4):1459-1483 (2020). PubMed PMID: 32076350. Scripts: https://github.com/chevrierlab/PME-seq

Decoding the Body Language of Immunity: Tackling the Immune System at the Organism Level
Chevrier N. Current Opinion in Systems Biology 18, 19-26 (2019). PubMed PMID: 32490290.

Kadoki M, Patil A, Thaiss C, Brooks DJ, Pandey S, Deep D, Alvarez D, von Andrian UH, Wagers AJ, Nakai K, Mikkelsen T, Soumillon M, Chevrier N. (2017) Organism-level analysis of vaccination reveals networks of protection across tissues. Cell 171, 398-413.

Mertins P, Przybylski D, Yosef N, Qiao J, Clauser K, Raychowdhury R, Eisenhaure TM, Maritzen T, Haucke V, Satoh T, Akira S, Carr SA, Regev A, Hacohen N, Chevrier N. (2017) An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Cell Reports 19(13):2853-2866.

Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson JT, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H, Carr SA, Regev A, Amit I, Hacohen N. (2011). Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits. Cell 147(4):853-67.

Complete list of publications:

https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40264281/?sort=date&direction=descending

Contact Information

Contact info
773-834-4567

Eckhardt Research Center  
Room 375
5640 South Ellis Avenue
Chicago, IL 60637

Knapp Center for Biomedical Discovery
Room 10122
900 East 57th Street
Chicago, IL 60637  

Assistant
Toni Molton
moltont@uchicago.edu