Biography

MS, Georgia Institute of Technology, Chemical Engineering, 2007

PhD, Georgia Institute of Technology, Bioengineering in 2008

Postdoctoral Fellow, Stanford University, Immunology, 2009-2015

Assistant Professor, University of Chicago, 2015-

Honors

NIH Pathway to Independence Award, 2014

Cancer Research Foundation Young Investigator Award, 2015

Research Interests

Huang’s research focuses on quantitative study of the protective immune function of conventional T cells, the immunosuppressive properties of regulatory T cells and the cytolytic function of natural killer cells. Utilizing state-of-the-art single-molecule and single-cell imaging techniques, single-molecule biomechanical assays as well as high-throughput systems biology methods, Huang’s group carries out basic scientific research, focusing on molecular mechanisms and immune function of cells, as well as translational researches with the objective of developing immunotherapies for infectious diseases and cancer.

Selected Publications

“Single-cell metabolic imaging reveals a RhoA-triggered glycolytic burst in motile endothelial cells,” David Wu, Devin Harrison, Teodora Szasz, Chih-Fan Yeh, Tzu-Pin Shentu, Angelo Meliton, Ru-Ting Huang, Zhengjie Zhou, Gokhan Mutlu, Jun Huang, Yun Fang. Nature Metabolism. 2021.

“Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets,” Haley Dugan, Christopher Stamper, Lei Li, Siriruk Changrob, Nicholas Asby, Peter Halfmann, Nai-Ying Zheng, Min Huang, Dustin Shaw, Mari Cobb, Steven Erickson, Jenna Guthmiller, Olivia Stovicek, Jiaolong Wang, Emma Winkler, Maria Lucia Madariaga, Kumaran Shanmugarajah, Maud Jansen, Fatima Amanat, Isabelle Stewart, Henry Utset, Jun Huang, Christopher Nelson, Ya-Nan Dai, Paige Hall, Robert Jedrzejczak, Andrzej Joachimiak; Florian Krammer, Michael Diamond, Daved Fremont, Yoshihiro Kawaoka, Patrick C. Wilson. Immunity, 2021.

“Nanotraps for the containment and clearance of SARS-CoV-2", Min Chen, Jillian Rosenberg, Xiaolei Cai, Andy Chao, Hsuan Lee, Jiuyun Shi, Mindy Nguyen, Thirushan Wignakumar, Vikranth Mirle, Arianna Joy Edobor, John Fung, Jessica Scott Donington, Kumaran Shanmugarajah, Yiliang Lin, Eugene Chang, Glenn Randall, Pablo Penaloza-MacMaster, Bozhi Tian, Maria Lucia Madariaga, Jun Huang. Matter. 2021. 

“Primary resistance to CD19-directed chimeric antigen receptor T-cell therapy in T-cell/histiocyte-rich large B-cell lymphoma,” Jonathan A Trujillo, James Godfrey, Yifei Hu, Jun Huang, Sonali M Smith, Matthew J Frigault, Zachariah DeFilipp, Daniel Appelbaum, Yonglin Pu, Nicholas Feinberg, Thomas Althaus, Michael R Bishop, Peter A Riedell, Justin Kline. Blood. 2021. 

“The Chimeric Antigen Receptor Detection Toolkit,” Yifei Hu, Jun Huang. Frontiers in Immunology, 2020. Download.

“Lattice light-sheet microscopy Multi-Dimensional Analyses (LaMDA) of T-cell receptor dynamics predict T-cell signaling states,” Rosenberg, J., Cao, D., Borja-Prieto, F., Huang, J. Cell Systems, 2020. 

“Visualizing Surface T-Cell Receptor Dynamics Four-Dimensionally Using Lattice Light-Sheet Microscopy,” J Rosenberg, J Huang. Journal of Visualized Experiments, 2020. 

“Cyclodextrin‐Derived Intrinsically Bioactive Nanoparticles for Treatment of Acute and Chronic Inflammatory Diseases,” Jiawei Guo, Dandan Li, Hui Tao, Gang Li, Renfeng Liu, Yin Dou, Taotao Jin, Lanlan Li, Jun Huang, Houyuan Hu, Jianxiang Zhang. Advanced Materials, 2019. 

“TCR–pMHC bond conformation controls TCR ligand discrimination,” Dibyendu K. Sasmal, Wei Feng, Sobhan Roy, Peter Leung, Yanran He, Chufan Cai, Guoshuai Cao, Huada Lian, Jian Qin, Enfu Hui, Hans Schreiber, Erin J. Adams and Jun Huang. Cellular and Molecular Immunology, 2019. 

“A Proresolving Peptide Nanotherapy for Site‐Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota,” Chenwen Li, Yang Zhao, Juan Cheng, Jiawei Guo, Qixiong Zhang, Xiangjun Zhang, Jiong Ren, Fengchao Wang, Jun Huang, Houyuan Hu, Ruibing Wang, Jianxiang Zhang. Advanced Science, 2019. Download

“T-Cell Mechanobiology: Force sensation, potentiation, and translation,” Devin L. Harrison, Yun Fang and Jun Huang. Frontiers in Physics, 2019. 

“The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection,” Xiangyu Chen, Guoshuai Cao, Jialin Wu, Xinxin Wang, Zhiwei Pan, Jianbao Gao, Qin Tian, Lifan Xu, Zhirong Li, Yaxing Hao, Qizhao Huang, Pengcheng Wang, Minglu Xiao, Luoyingzi Xie, Shupei Tang, Zhenyu Liu, Li Hu, Jianfang Tang, Ran He, Li Wang, Xinyuan Zhou, Yuzhang Wu, Mengjie Chen, Beicheng Sun, Bo Zhu, Jun Huang & Lilin Ye. Cellular and Molecular Immunology, 2019. 

“A self-illuminating nanoparticle for inflammation imaging and cancer therapy,” Xu, X., An, H., Zhang, D., Tao, H., Dou, Y., Li, X., Huang, J. and Zhang, J. Science Advances, 2018 

“Stable, small, specific, low-valency quantum dots for single-molecule imaging,” Jungmin Lee, Xinyi Feng, Ou Chen, Moungi G Bawendi, Jun Huang. Nanoscale, 10, 2018 

“CD8+ T cells and NK cells: parallel and complementary soldiers of immunotherapy,” Jillian Rosenberg, Jun Huang. Current Opinion in Chemical Engineering, 19, 9-20, 2018 

“Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells ,” Yunlong Zhao, Devin L. Harrison, Yuran Song, Jie Ji, Jun Huang, Enfu Hui. Cell Reports, 24, p379–390.e6, 2018 

“The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes,” Ben S. Wendel, Daniel Del Alcazar, Chenfeng He, Perla M. Del Río-Estrada, Benjamas Aiamkitsumrit, Yuria Ablanedo-Terrazas, Stefany M. Hernandez, Ke-Yue Ma, Michael Betts, Laura Pulido, Jun Huang, Phyllis A. Gimotty, Gustavo Reyes-Terán, Ning Jiang, Laura F. Su. Science Immunology, 2018 

BPHYS Students

Devin Harrison, PhD

Andrés Moya Rodríguez, PhD