The Big Picture
I study the gene regulatory networks that govern cell fate commitment using genome-wide and single-cell measurements.
Complex gene regulatory networks control the development of functionally diverse immune cells from hematopoietic stem cell precursors in mammals. Since these networks consist of numerous regulatory factors that are often densely interconnected and feature pervasive feedback, it is challenging to identify the regulatory programs that characterize lineage commitment. By developing specific computational analyses for genome-wide and single-cell measurements of differentiating cells, I intend to uncover changes in gene regulation that correspond to developmental decisions. In particular, I am applying these analytical techniques to the development of innate lymphoid cells, a relatively recently appreciated group of innate-like immune cells that are important drivers of various immune programs.