The Big Picture

I study the mechanism by which DNA is rearranged by Sin, a serine recombinase from Staphylococcus aureus

In order to recombine DNA in Staphylococcus aureus, Sin recombinase forms a swivel interface around which the protein and DNA rotate. My goal is to better understand how the changes during recombination. I use x-ray crystallography and computation methods, such as normal mode analysis, to understand protein structural changes.