The Faculty

Focus

The Weizmann group develops manipulates DNA to develop functional structures and superior sensors that can be controlled upon demand.

Biography

Born Israel, 1973.
ORT Braude Academic College of Engineering, B.Tech., 2000.
Hebrew University, M.Sc, 2002.
Hebrew University, Ph.D., 2007.
MIT, Postdoctoral Associate, 2008-2011.
University of Chicago, Assistant Professor, 2011-

Accolades

2006 The Rudolf Graf Prize, Hebrew University.
2006 Johanna Friedlander Memorial Prize, Hebrew University.
2004 Kaye Award for Innovation, Hebrew University.
 

Research Interests

Nanoscience offers unparalleled opportunities for designing ground-breaking generations of medical diagnostics and research platforms. Research in the Weizmann laboratory is based on a multidisciplinary field interfacing with biology, chemistry, nanotechnology and materials science, where large research directions take place. My group will focus on new ways to improve our ability to manipulate DNA, to develop remarkable and desired functional structures and superior sensors that can be controlled upon demand. My research interests are concerned with the application of nanowire based electronic/optical devices in the biological and chemical detection area, with the aim of exploring and exploiting the nanoscale advantages in the world of material chemistry, to address significant chemical, biochemical and technological problems. One of the central themes of my research program is to approach nanoscience from a multidisciplinary perspective by integrating biomaterials (nucleic acids and proteins), inorganic materials, carbon nanotubes and small molecules via non-covalent and covalent interactions, to develop new hybrid materials with emergent properties. My objective is to establish a fascinating and attractive interdisciplinary field that can join students, post-docs and researchers from different science areas. I believe that the multidisciplinary emphasis of my research will create an atmosphere of varied and collaborative work that will stimulate the students’ motivation and promote their independence and ability to explore new and challenging areas.

Research topics:

  • Bionanotechnology-Bioelectronics & Optobioelectronics: Amplification means for bioanalytical systems, using biological materials and photo-switches to create active electrical components.
  • Functional Materials and Nanomaterials: Metallic nanoparticles, magnetic nanoparticles, nanorods and nanowires for bioelectronic and biomedical applications.
  • Biomolecule-Based Nanostructures: Functional interfaces composed of biomaterials and nano-objects, supra-molecular hybrid systems with complex molecular/biomolecular nanoarchitecture.
  • Nanocircuitry: Based on biotemplates, supramolecular approach for the self-assembly of functional nanowire-based carbon nanotube materials.
  • Biosensing: Based on integrated systems with complex molecular architecture, self-powered biosensors, DNA-machine based sensors.
  • Gene Expression: Study fundamental aspects of the chemistry of DNA/peptide assembles, and the applications in controllable gene expression systems mediated by supramolecular interactions.

 

Undergraduate students, graduate students, and postdoctoral researchers are involved in interdisciplinary areas including organic chemistry, biochemistry, macromolecular structure (nucleic acids and proteins), material science, and nanotechnology.

Selected References

Y. Weizmann, D. M. Chenoweth and T. M. Swager. DNA-CNT Nanowire Networks for DNA Detection. J. Am. Chem. Soc., 133, 3238-3241 (2011).

Y. Weizmann, D. M. Chenoweth and T. M. Swager. Addressable Terminally-Linked DNA-CNT Nanowires. J. Am. Chem. Soc., 132, 14009-14011 (2010).

Y. Weizmann, J. Lim, D. M. Chenoweth, and T. M. Swager. Regiospecific Synthesis of Au-Nanorod/SWCNT/Au-Nanorod Heterojunctions. Nano lett., 10, 2466-2469 (2010).

O. I. Wilner, Y. Weizmann, R. Gill, O. Lioubashevski, R, Freeman and I. Willner. Enzyme cascades activated on topologically programmed DNA scaffolds. Nature nanotechnology, 4, 249-255 (2009). Selected for the cover picture of the journal. Covered by Nature Nanotechnology 4, 211-212 (April 2009) doi:10.1038/nnano.2009.66 News and Views. Covered by Nature Chemistry (9 April 2009) doi:10.1038/nchem.210.

Y. Weizmann, A. B. Braunschweig, O. I. Wilner, Z. Cheglakov and I. Willner. A polycatenated DNA scaffold for the one-step assembly of hierarchical nanostructures. PNAS, 105, 5289-5294 (2008).

Y. Weizmann, M. K. Beissenhirtz, Z. Cheglakov, R. Nowarski, M. Kotler and I. Willner. A Virus Spotlighted by an Autonomous DNA Machine. Angew. Chem. Int. Ed., 45, 7384-7388 (2006). Covered by Nature News: doi:10.1038/news061106-19.

Y. Weizmann, Z. Cheglakov, V. Pavlov and I. Willner. An Autonomous Fueled Machine that Replicates Catalytic Nucleic Acid Templates for the Amplified Optical Analysis of DNA. Nature Protocols, 1, 554-558 (2006).

Y. Weizmann, Z. Cheglakov, V. Pavlov and I. Willner. Autonomous Fueled Mechanical Replication of Nucleic Acid Templates for the Amplified Optical Detection of DNA. Angew. Chem. Int. Ed., 45, 2238-2242 (2006). Selected as Very Important Paper (VIP), Selected for the cover picture of the journal. Covered by Nature 440, 584-585 (29 March 2006) doi:10.1038/440584a Research Highlights. Covered by Molecular BioSystems: Hot off the Press: DOI: 10.1039/b605372f. Selected for Faculty of 1000 Biology.

F. Patolsky, Y. Weizmann and I. Willner. Actin-Based Metallic Nanowires as Bio-Nanotransporters. Nature Materials, 3, 692-695 (2004). Covered by Nature Materials 4, 115-116 (February 2005) doi:10.1038/nmat1315 News and Views.

F. Patolsky, Y. Weizmann and I. Willner. Long-Range Electrical Contacting of Redox Enzymes by SWCNT Connectors. Angew. Chem. Int. Ed., 43, 2113-2117 (2004).

Y. Weizmann, F. Patolsky, O. Lioubashevski and I. Willner. Magneto-Mechanical Detection of Nucleic Acids and Telomerase Activity in Cancer Cells. J. Am. Chem. Soc., 126, 1073-1080 (2004).

Y. Weizmann, F. Patolsky, E. Katz and I. Willner. Amplified DNA Sensing and Immunosensing by the Rotation of Functional Magnetic Particles. J. Am. Chem. Soc., 125, 3452-3454 (2003).