The Faculty

Focus

Manipulation and measurement of the surface properties of polymers, surface phenomena such as adhesion, friction, and biocompatibility, and new materials based on self-assembly of synthetic and bio-inspired materials

Biography

Arnold and Barbara Silverman
Professor and Chair,
Department of Bioengineering,
University of California,
Berkeley, and Berkeley National
Laboratory

Richard A. Auhll Professor and
Dean, College of Engineering,
University of California, Santa
Barbara

Professor Chemical Engineering,
Materials, University of
California, Santa Barbara

Director of the Biomedical
Engineering Institute and Head
of Chemical Engineering and
Materials Science, University of
Minnesota

Earl E. Bakken Professor of
Biomedical Engineering,
University of Minnesota

Shell Distinguished Chair in
Chemical Engineering,
University of Minnesota

Education

PhD, Polymer Science
University of Massachusetts

BChE, Northwestern University

BPHYS Student

John Barrett

Overview

Matthew Tirrell, a pioneering researcher in the fields of biomolecular engineering and nanotechnology, is the founding Pritzker Director of the Institute for Molecular Engineering.

Tirrell specializes in the manipulation and measurement of the surface properties of polymers, materials that consist of long, flexible chain molecules. His work combines microscopic measurements of intermolecular forces with the creation of new structures. His work has provided new insight into polymer properties, especially surface phenomena, such as adhesion, friction, and biocompatibility, and new materials based on self-assembly of synthetic and bioinspired materials.

Tirrell began his academic career in 1977 at the University of Minnesota, where he served as Shell Distinguished Chair in Chemical Engineering, Earl E. Bakken Professor of Biomedical Engineering, director of the Biomedical Engineering Institute, and head of Chemical Engineering and Materials Science. Tirrell moved to the University of California, Santa Barbara, in 1999, where for a decade he was professor of Chemical Engineering, Materials, Biomolecular Science, and Engineering, and Richard A. Auhll Professor and Dean of the College of Engineering.

Select Bibliographies

The non-peptidic part determines the internalization mechanism and intracellular trafficking of peptide amphiphiles. Missirlis D, Teesalu T, Black M, Tirrell M. PLoS One. 8(1):e54611. (2013) PMCID: PMC3547919

Thermodynamic characterization of polypeptide complex coacervation. Priftis D, Laugel N, Tirrell M. Langmuir. 28(45):15947-57. (2012)  PMID: 23083137

Liposome encapsulation of a photochemical NO precursor for controlled nitric oxide release and simultaneous fluorescence imaging. Ostrowski AD, Lin BF, Tirrell MV, Ford PC. Mol Pharm. 9(10):2950-5. (2012) PMID: 22953784

Structural effects and lipid membrane interactions of the pH-responsive GALA peptide with fatty acid acylation. Lin BF, Missirlis D, Krogstad DV, Tirrell M. Biochemistry. 51(23):4658-68. (2012) PMID: 22591394

Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo. Black M, Trent A, Kostenko Y, Lee JS, Olive C, Tirrell M. Adv Mater. 24(28):3845-9 (2012) PMID: 22550019

Effect of the peptide secondary structure on the peptide amphiphile supramolecular structure and interactions. Missirlis D, Chworos A, Fu CJ, Khant HA, Krogstad DV, Tirrell M. Langmuir. 27(10):6163-70. (2011) PMCID: PMC3103120.

Toll-like receptor-mediated adjuvanticity and immunomodulation in dendritic cells: Implications for peptide vaccines. Mitchell D, Yong M, Raju J, Willemsen N, Black M, Trent A, Tirrell M, Olive C. Hum Vaccin. 7 Suppl:85-93. (2011) PMID: 21245658

Self-assembly and applications of solid-state nucleic acid films, S. Gajria, T. Neumann and M. Tirrell, WIRE Nanomed. Nanobiotech., 3, 479-500 (2011) PMID: 21638788.

Neural stem cell adhesion and proliferation on phospholipid bilayers functionalized with RGD peptides, B. Ananthanarayanan, L. Little, D.V. Schaffer, K.E. Healy and M. Tirrell, Biomaterials, 31, 8706-8715 (2010) PMCID: PMC2949453.

Promotion of osteoblast proliferation on complex coacervation-based hyaluronic acid – recombinant mussel adhesive protein coatings on titanium, D.S. Hwang, J.H. Waite and M. Tirrell, Biomaterials, 31, 1080-1084 (2010) PMCID: PMC3547919

Mechanisms of Peptide Amphiphile Internalization by SJSA-1 Cells in vitro, D. Missirlis, H. Khant and M. Tirrell. Biochemistry, 48, 3304-3314 (2009) PMCID: PMC2713106.

Cell Adhesion and Growth to Peptide-Patterned Supported Lipid Membranes, D. Stroumpoulis, H. Zhang, L. Rubalcava, J. Gliem and M. Tirrell, Langmuir, 23, 3849-3856 (2007).

Effect of RGD Secondary Structure and the Synergy Site PHSRN on Cell Adhesion, spreading and specific integrin engagement, S. Ochsenhirt, E. Kokkoli, J .McCarthy and M. Tirrell, Biomaterials, 27, 3863-3874 (2006)

Collective and Single-Molecule Interactions of a5b1. Integrins”, E. Kokkoli, S.E. Ochsenhirt and M. Tirrell, Langmuir, 20, 2397-2404 (2004).

Adhesion and Friction Mechanisms of Polymer-on-Polymer Surfaces, N. Maeda, N. Chen, M. Tirrell and J.N. Israelachvili, Science, 297, 379-382 (2002).