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Juan de Pablo
Liew Family Professor, Institute for Molecular Engineering
Affiliation: Institute for Molecular Engineering
Thermophysical properties of fluids and solids at a molecular level
A fellow of the American Academy of Arts and Sciences as well as the American Physical Society, de Pablo has also received the 2011 Charles Stine Award from the American Institute of Chemical Engineers.
He received his PhD in chemical engineering from the University of California, Berkeley, and his BS in chemical engineering from the National University of Mexico. He conducted postdoctoral research in materials science at the Institut für Polymere in Zurich.
Knowing and understanding the thermophysical properties of fluids and solids, respectively, is essential for designing efficient chemical processes and for developing new materials. Our research investigates the thermophysical properties of fluids and solids at a molecular level, and uses molecular-thermodynamic models and statistical-mechanical principles.
Molecular simulations are important to our research. Using advanced methods and powerful computers, we examine molecular motion and probe the microscopic structure of fluids and solids. Based on these studies, we try to explain and predict the macroscopic behavior of these systems. These predictions are then compared to our and our collaborators experimental laboratory data.
Some of the common problem that we work with are:
- Pack it up, Pack it in: Unraveling H-NS Mediated Genome Packaging. Freeman GS, de Pablo JJ. Biophys J. 2013 Apr 2;104(7):1397-8. (2013) PMID: 23561514
- Colloid-in-Liquid Crystal Gels that Respond to Biomolecular Interactions. Agarwal A, Sidiq S, Setia S, Bukusoglu E, de Pablo JJ, Pal SK, Abbott NL. Small. Apr 2. doi: 10.1002/smll.201202869. (2013) PMID: 23554243
- Effects of 3D microwell culture on growth kinetics and metabolism of human embryonic stem cells. Azarin SM, Larson EA, Almodóvar-Cruz JM, de Pablo JJ, Palecek SP. Biotechnol Appl Biochem. 59(2):88-96. (2012) PMID: 23586789
- Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor. Middleton CT, Marek P, Cao P, Chiu CC, Singh S, Woys AM, de Pablo JJ, Raleigh DP, Zanni MT. Nat Chem. 4(5):355-60. (2012) PMID: 22522254
- Dimerization of helical β-peptides in solution. McGovern M, Abbott N, de Pablo JJ. Biophys J. 102(6):1435-42. (2012) PMID: 22455927
- Parallel β-sheet vibrational couplings revealed by 2D IR spectroscopy of an isotopically labeled macrocycle: quantitative benchmark for the interpretation of amyloid and protein infrared spectra. Woys AM, Almeida AM, Wang L, Chiu CC, McGovern M, de Pablo JJ, Skinner JL, Gellman SH, Zanni MT. J Am Chem Soc. 134(46):19118-28. (2012) PMID: 23113791
- Modulation of Wnt/β-catenin signaling in human embryonic stem cells using a 3-D microwell array. Azarin SM, Lian X, Larson EA, Popelka HM, de Pablo JJ, Palecek SP. Biomaterials. 33(7):2041-9. (2012) PMID: 22177620
- 2DIR spectroscopy of human amylin fibrils reflects stable β-sheet structure. Wang L, Middleton CT, Singh S, Reddy AS, Woys AM, Strasfeld DB, Marek P, Raleigh DP, de Pablo JJ, Zanni MT, Skinner JL. J Am Chem Soc. 133(40):16062-71. (2011) PMID: 21916515
- GNNQQNY--investigation of early steps during amyloid formation. Reddy AS, Chopra M, de Pablo JJ. Biophys J. 17;98(6):1038-45. (2010) PMID: 20303861
- Solution structures of rat amylin peptide: simulation, theory, and experiment. Reddy AS, Wang L, Lin YS, Ling Y, Chopra M, Zanni MT, Skinner JL, De Pablo JJ. Biophys J. 98(3):443-51. (2010) PMID: 20141758
- The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells. Mohr JC, Zhang J, Azarin SM, Soerens AG, de Pablo JJ, Thomson JA, Lyons GE, Palecek SP, Kamp TJ. Biomaterials. 31(7):1885-93. (2010) PMID: 19945747
- Density multiplication and improved lithography by directed block copolymer assembly. Ruiz, R; Kang, H.M.; Detcheverry, F.A.; Dobisz, E; Kercher, D.S.; Albrecht, T.R.; de Pablo, J.J.; Nealey, P.F. Science 321 (5891): 936-939 (2008) PMID: 18703735.
- Directed self-assembly of block copolymers for nanolithography: Fabrication of isolated features and essential integrated circuit geometries. Stoykovich, M.P.; Kang, H; Daoulas, K.C.; Liu, G; Liu, C.C.; de Pablo, J.J.; Mueller, M; Nealey, P.F.. ACS Nano 1 (3): 168-175 (2007) PMID: 19206647.
- Directed assembly of block copolymer blends into nonregular device-oriented structures, Stoykovich, M. P.; Muller, M.; Kim, S. O.; Solak, H. H.; Edwards, E. W.; de Pablo, J. J.; Nealey, P. F., Science 308 (5727), 1442-1446 (2005) PMID: 15933196.
- Epitaxial self-assembly of block copolymers on lithographically defined nanopatterned substrates, Kim, S. O.; Solak, H. H.; Stoykovich, M. P.; Ferrier, N. J.; de Pablo, J. J.; Nealey, P. F., Nature 424 (6947), 411-414 (2003) PMID: 12879065.